Cd1a negative langerhans cell histiocytosis: A case report

Cd1a negative langerhans cell histiocytosis: A case report

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Langerhans cell histiocytosis (LCH) is a rare histiocytic tumour in adult.We hastu goyal report a case of LCH involving skull bones in a 35year old lady who presented with fever, headache and diabetes insipidus since two years.Radiological examination revealed osteolytic lesions in the parietal and occipital bones along with a solid, enhancing lesion in the pituitary infundibulum.Osteolytic lesions showed ttypical histomorphology of LCH on light microscopy and on IHC it was positive for SI 00 but negative for CD1 a.

LCH with thorogood 804-3236 CD1 a negativity is very rare and hence we are presenting this case.